Sheeple

Right to terminate lives?

The sight of feral MAGA supporters taking to the streets in an attempted mass extinction event, protesting their constitutional right to dumb it down, has me musing on US vs Australian psyche. CoVID-19 new case rates here have dropped 9-fold after mandated stay-home ‘unless …..’, and we’re meekly compliant. However the USA’s outstanding effort to hold #1 spot in having the most fatalities isn’t world leadership to aspire to. Likewise, mandatory seatbelt laws beginning in 1970 were proven successful in dropping our roadtoll, whereas in 16 of 50 States Americans still can’t be pulled over by police for not wearing one.

There’s a flipside. Medication harms are hardly ever brought to our TGA’s attention by consumers, and the Database of Adverse Event Notifications (DAEN) is worthless. For the #1 worst drug for numbers of reported side-effects in the USA in 2015, Xarelto, the DAEN lists 123 Australian complaints for their beloved dying as a result of it. The US FDA site at fis.fda.gov is a simple dashboard, and shows 15,557 died – most bleeding from their arse. Bummer!

With a 13:1 population difference (and ignoring prescription rates for now), Americans are ten times more likely than ‘Strayans to cry ‘bloody murder’ at their doctor. For the choice to prescribe Xarelto is difficult to justify.

Old-school anti-coagulant warfarin, in use since 1954, and likewise clopidogrel, are each still prescribed three times as much as Xarelto in 2017, have a fraction the number of adverse events. They’re roughly 20 times safer, and even the newer alternative of Eliquis is killing Xarelto in the marketplace – but at a slightly lower rate in the hospitals. So why was an older friend suffering a leg clot just put onto Xarelto as first option? Lacking the transparency brought by Obama’s Sunshine Act, I can’t comment on whether pharmaceutical company sponsorship influences Australian Dr’s prescribing patterns. It’s fair to speculate that Johnson and Johnson had to adopt aggressive marketing tactics in order to overcome the hits to business from vaginal mesh implants, and opioid & Risperdal (anti-psychotic inappropriately promoted as a sedative in nursing homes) damage.

Partnered with Bayer in marketing Xarelto, J&J last year settled out-of-court for $USD775m for failing to adequately forewarn of bleeding risk.

*Disclaimer. The author didn’t even study biology at school, but a sense of smell for rat (o/dosed on warfarin?) developed doing a Master of Clinical Research at Pfizer’s partner Monash Uni.

Anti-antioxidants?

The Times newspaper shared this article under a tag of red wine’s possible blood pressure benefit (caveat: sufficient intake of the molecule for lowering BP requires 1,000 bottles/day). This line is less nonsensical… “by oxidising a protein called PKG1a in the blood vessel wall.” The free radical worm* turns.

The previous post considered hyperbaric oxygen therapy (HBOT) as destructive to viruses. Speculation attributing perplexing conditions to common herpes viruses eg h. simplex HSV or h. virus 6 in Alzheimer’s or hypothyroidism/Hashimotos is supported by the lab. Indestructability of HSV by the free radical hydrogen peroxide wasn’t long ago explained by discovery of catalase in the virus, perhaps only mitigated by increasing peroxide levels. Now consider this study of HBOT treating drug resistant bacterial infections where 3 weeks of the meds had failed.

Prior to meds, inflammation marker CRP (C-reactive protein, normal level<1) averaged 7.7, after meds 7.1, and after HBOT 0.8! The world faces a Superbug crisis, by virtue of our greed. Offshore manufacture of antibiotics in China and India creates free availability of drugs, and poor sanitation ie no toilets lets Antibiotic Microbial Resistance spread rapidly. Oxygen as a drug may eventually have to be used, eh? The running cost of an oxygen concentrator is ~7c per hour. Iran, Israel, and Turkey are researching the applications – unfettered by pharmaceutical industry control. Another microbe: the fungus, treated here at Alfred hospital and described in a glowing press release. Did you note that the idea came from a googling family member, not a medico?

Industrial cleaners tackling toxic contamination such as that left by meth labs, hoarding & rat infestation, etc use unattended free radical generators to bomb the bug: peroxide and hydroxyl. They’ll kill you, too… and yet your body’s processing of oxygen makes these, more so if an excess of oxygen is supplied. Needless to say, the Diving & Hyperbaric Medicine faculty of the College of Anaesthetists refuses to correspond on such matters. An investigative journalist’s report on their commercial allegiances gives a clue as to why meds are seen as the only answer.

*In Shakespearean times the ‘worm’ meant dragon. Apt analogy for fire-breathing monsters when one such oxidant is hydrogen peroxide (rocket fuel).

Don’t go viral

Unable to garner any interest in a human-rights violation, explained previously at Framework or Façade?, I’ll retry … perhaps I’d been too flippant, which was my way of dealing with the shock 😦

Two atrocities

On the left is the SmART trial for Drug Conservation (DC), rather than fully-dosed AntiRetroviralTherapy (dotted line), for half of five thousand HIV+ recruited participants. It’s obvious within a few months that the DC proposal for minimal dosing sent HIV viral in those unlucky enough to be randomised to that group. Yet the study was allowed to run four years, and only at the 5th meeting of the ‘safety’ board was the trial stopped and everyone treated with full ART. The study had been funded for six years to investigate cardiovascular outcomes, which didn’t eventuate, but the money kept coming.

The doctors then ran another similar proposal – deferred start of ART until CD4+ (T-helper cells are your immunity) counts drop below 350. Again apparent as a terrible idea within months. This time it was stopped after five years, as an unsafe practice. Another five thousand recruits were allocated 50/50 by the toss of a coin to an alternative that not only increased their risk of AIDS, but also that of spreading HIV.

I’ve written to Vice-Chancellors at Monash and UNSW, two of the participating institutions, complaining that the only Ethics Committee response had been: “Professor Emery is now at the University of Queensland. He is neither the lead or contact author for the relevant article...” finger-pointing by the Director of Research Ethics. No replies. Now consider the only, poor quality study of * Hyperbaric Oxygen (HBOT) for HIV by a nurse and clinic director. Six HIV+ patients, each having received 3-300 sessions of HBOT all dropped their HIV count to 5 or less virions per million cells – thus now considered HIV negative. Never cured, n.b. as with ART’s cocktail of ~3meds, it’s just life-preserving. Indeed CD4+ counts never recovered – once transcribed into your DNA, the virus has wrought permanent damage. But an interesting idea, worthy of further study… however such has never been undertaken in the subsequent two decades. Only two people globally have actually been cured of HIV, due to transplanting an immune system. ART remains vital.

[Victorian Health Minister] Ms Hennessy wants the ACCC to investigate claims made by Hypermed surrounding treatments for cancer, HIV and cerebral palsy. Leaving aside the actual claim being ‘adjunct therapy’ to chemo/radiotherapy (as is also delivered by Monash/Alfred hospital hyperbaric), along with the fact that the consumer watchdog ACCC has no jurisdiction on medical matters, it’d seem more appropriate to demand answers of those institutions refusing to conduct more rigorous investigations. Here’s my limited understanding of the justifications for doing such.

Oxidative Stress. Lipids are structural components of cell membranes. It’d been suggested that lipid peroxidation was analogous to ‘rusting’, that free radicals damaged cells, so antioxidants would help us live longer & look more beautiful etc. When oxygen is breathed in, eventually exiting in carbon dioxide, gaining electrons (thus causing oxidation) creates free radicals at each step. This is normal, and sometimes really slimming too. When glucose is depleted fatty lipids are burned instead, so best we ignore advertising’s simple assumption that free radicals are damaging. We run on them: superoxide (1 electron stolen) and hydrogen peroxide (2 e-).

An HBOT advocate discusses the concept of attacking viruses’ protective lipid envelope, suggesting potential against HIV, Epstein-Barr ie glandular fever (EBV), and Herpes Simplex (HSV). My interest is suddenly piqued, given the early trial successes of IMC-1 against fibromyalgia using a combo of HSV antiviral famciclovir and celecoxib (HSV replication is reliant on imflammatory COX, and the benefit of inhibitors has been known for 4 decades). Then link to HSV’s association with Alzheimer’s (AZH) and excitement mounts… oooh there’s a study of HBOT for AZH … ohhh sorry, it’s on mice. EBV is implicated in chronic fatigue syndrome so three of the greatest medical perplexes could well be treated, just with something in the air we breathe!

But nobody’s looked into it. Institutions don’t care for much but pharmacology, since research is costly. Their industry is profitable tho’.

Smashing together of data

A study has been run on HBOT for shingles (caused by varicella-zoster virus) by Peng et al, and it looked promising. I conducted a systematic review of the literature on other gold-standard Randomised Controlled Trials of HBOT for various other painful neuropathies believed by some to result from viruses. Monash’s chief biostatistician, Prof Forbes, questioned my ‘fudging data’ since it was rare for such consistent results especially across disparate conditions.

Note that the 5 studies came from China, Turkey & Israel. Pharma totally controls what investigations are allowed to happen in the West.

* What/why is Hyperbaric? Oxygen is a vasoconstrictor, so the body’s wonderful homeostasis balances richer oxygen intake with reduced vascular flow. But administering O2 under pressure cheats the system: it floods every tissue without regard for bloodflow.

 

The witches’ prophecy of Macbeth’s promotion to Thane of Cawdor (Baron, or Earl), as reward for his fight saving King Duncan, has only just been fulfilled. Yet he can’t enjoy the moment, as his thoughts run away with what is yet to be – their other prediction that he’ll be King. This rumination troubles him, as he contemplates murder, and all else is as nothing. Plans and possibilities take over completely.

Two decades ago fMRI studies showed the brain’s resting-state connectivity to be just as active as when deeply focused. Raichle then showed neural energy consumed, in what he termed the ‘default network’, to be just 5% below levels in tasking (considering that this organ burns one fifth of our energy, and double that in adolescence, it is a very inefficient rest). The circuits which light up are very specific, unlike noisy & chaotic concentration networks, and match those when a subject is asked to imagine their future.

“The structural-functional connectome and the default mode network of the human brain”. NeuroImage, 2013.

Humans are perhaps uniquely prospective, running simulations on future possibility whenever possible. This can lead to unfortunate consequence in failing to be mindful of the present, or leading into dangerous speculation. We had been warned: Shakespeare wrote Banquo’s lines in the scene prior warning Macbeth of temptation that ‘instruments of Darkness win us to our harm‘ over four centuries ago; and the Buddha two millennia prior. Fearful futures are often suppressed through anxiolytics such as Valium or Lyrica, to name two of the most dangerous drugs. Such abuse is on the increase, by persons feeling isolated and suffering troubling thoughts.

Society grows ever less connected, and the social media that we’ve become reliant upon has increased our Darkness. Two hour documentary ‘The FaceBook Dilemma‘ reveals our networking to be manipulated for commercial and political gain. It’s horrifying to consider Putin’s strategy of seeding hyper-patriotic groups (each either virulently pro-Clinton or Trump) to have also been used by Duterte in the Philippines, and Myanmar’s inciting genocide against the Rohingya. We connect to  groups based on agenda and issue, oblivious to their construct of a polarised and fragmented society. A deceit, but all the while we’re supposedly exercising free will in chat with these unseen ‘Friends’. Einstein was of the same mind as Donne (No man is an island…) in writing: “A human being is a part of the whole, called by us ‘Universe’, a part limited in time and space. He experiences himself, his thoughts and feelings as something separated from the rest — a kind of optical delusion of his consciousness.”

I’m following just a few on Twitter, instead. @Gergyl is a brilliant mind, and one whose climate science skills informs my winter planning too. Onetime BMJ editor Richard Smith also cleverly articulates our place in time through his blog drawing heavily on literature for inspiration. For we aren’t spatial islands, within some fixed time period. We’re inherently seeking connected-ness with others and, if the Buddhists are right, we’re spirits incarnate in endless cycles. I’m of the opinion that the past was lived (by others) so as to inform the present. Thus we evolve.

The Hon George W. Cole, cousin to my great great great grandfather.

Perhaps genealogy speaks to us. Wikipedia offers several motives for tracing ancestry, including placing one’s family in a historical picture. Unable to find a picture of my forebear Thomas Cornelius Cole, I’m nonetheless feeling kinship to G.W. Cole. Both cousins * came to Melbourne in 1840 – one a market gardener, t’other an ex-Naval Officer (from humble entry as a Midshipman).

They were bold pioneers, experiencing success and great wealth. Today’s structured society holds little respect for maverick entrepreneurs – despite business paradigms embracing ‘disruptive thought’ platitudes, I can assure you that playing the game pays out better in the end. I nonetheless take inspiration from their endeavours, and find solace for impossible morning hair as being in my genes. And this connection to past greatness helps me see into a future ripe with possibility.

 

* Presumed cousins. All from northern England, similar ages, area settled, passions eg horticulture, etc.

 

 

Bad Medicine (part 5)

Martin Seligman’s 2018 ‘The Hope Circuit’ is his autobiographical account of the field of Positive Psychology’s (PP) evolution. As a popularly elected President of the American Psychology Ass’n (APA), despite being unpopular with legacy professorial clinicians, his object was usurp of the American Psychiatric Assn’s cornerstone: mental disorders. This other APA manages the Diagnostic & Statistical Manual (DSM), which establishes thresholds of ‘what’s normal’ in behavior and perception. The DSM pigeon-holes us, much like the museum pins taxonomy labels on insects, but PP refutes the idea of correcting faults. Better that we play to strengths, and let the defects be.

Nailed to a diagnosis

The last chapter is his epiphany – in his seventies, he realizes that he’s been wrong all along. His theory of learned helplessness had been proven in the labs – beat an animal down with inescapable suffering, and they’ll lose the will to fight their way out of the predicament. But his colleague Steve Maier turned that upside down. Our vulnerable infants are nurtured through their helplessness, but based upon success against adversity they build a neural circuit, simple neuroplasticity, that gives resilience. I repeat: we learn to thrive from achieving, else feebly succumb and remain dependent for life.

To be fair to Marty, the neuroscience had only recently matured so as to enable Maier & Watkins’ breakthrough. Though the seminal work is a dozen years old, it’ll be awhile yet before its significance drives psychotherapy dinosaurs into extinction. My personal enthusiasm is kindled by Linda Watkins’ other, amazing insight into fibromyalgia, where along with Prof Younger and Adelaide Uni’s Prof Mark Hutchinson this autoimmune disorder was attributed to the brain’s innate defence mechanism – glial response to perceived viral attack* . Sufferers can’t yet take comfort from that breakthrough, there’s more Randomised Control Trials of an anti-viral combo (IMC-1) to be done over many years.

Back to the ‘hope circuit’. By default the brainstem’s DRN produces serotonin, which calms down the ‘fight or flight’ sympathetic nervous system – but also amplifies anxiety driven by the amygdala in the limbic system. I’ll re-word that for emphasis: serotonin treats panic attacks, but worsens fear. One could ponder the backlash of research, through the likes of David Healy’s Rxisk.org, asking why antidepressants that elevate serotonin have side-effects such as increased suicidality. The simple ‘chemical imbalance’ theory has been thrown out awhile ago (don’t get me started as to whether bloods to review serotonin levels in patients should be analysed, before being handed the happy pills on a presumption of necessitating boost via an SSRI), because we’re not machines but rather systems. Tinker with one process and another will compensate. All this isn’t in the pharmaceutical company brochures, though it’s been well-known for two decades. And the growth market is for teenagers, despite halting the formation of circuits required for later resilience.

DRN hijack of emotions is dampened by previous cognitive rewards from the Pre-Frontal Cortex (PFC, the learning brain) using successful control over situations to increase kinase proteins – described as an ‘immunization’. In animal models the dissected brains are tested for a change to successfully build resilience, and in the last few years studies have been designed for humans using fMRI. Do-it-yourself at home is a no-brainer. PP gives all the tools you need to focus on success, and protect your brain: simply do the survey to ascertain strengths, then determine how best to use them. If that fails, then seek professional help… being prescribed an anti-depressant isn’t the worst possible outcome from a trip to the doctor – script for Lyrica holds that ignominy.

The 2009 Stanford study damning Lyrica as blocking formation of new synapses, connections between neurons, has been cited a further 245 times. The most recent further investigation ‘The Îą2δ-1–NMDA receptor coupling is essential for corticostriatal long-term potentiation and is involved in learning and memory’ describes how gabapentinoids break the hope circuit (nasty biochem, but Lyrica and Neurontin are designed to block Îą2δ-1 Calcium subchannels, and the PFC pathway to moderate the DRN is via ERK->NMDA Calcium channels. Please don’t ask for an explanation).

This fresh knowledge has no commercial application, PP will never be packaged in a pill (picrotoxin is used in research as an ‘anti-gabapentinoid’ to artificially create PFC->DRN control, but is deadly!). Worse, the accreditation Master of Applied PP is only taught in Australia at Melbourne Uni – where it’s sequestered away in the School of Education, not Health. An inceptual program is underway centred on Heathmont College, which follows Geelong Grammar’s wonderful work. It’s unlikely that the medical industry’s stranglehold on wellbeing will loosen without generational change through these schoolkids achieving professorship. TheMindfulGap was a partnership with my then wife, doing all we could to prepare the way for chronic illness sufferers to escape helplessness. Hopefully someday someone’s children will value those efforts.

Good luck in the meantime, Geoff

 

* So what? Well to measure societal suffering through subscribers to forum PatientsLikeMe.com, where the medically disenfranchised seek answers to their condition, 106 thousand fibromites vastly outnumber Major Depressive Disorders 2:1, or backpain 100:1, or arthritics 4:1. Great research tackles great problems.

Bad Medicine (Pt4)

cont’d

A few years back I was volunteer non-emergency driver for Red Cross ambulant patients going to clinical appointments. The car was fully booked, and the third for the backseat was my last pickup. They had an an older Left Ventricle Assist Device, with huge powerpack. “Would you all squeeze up on the backseat to make room for the artificial heart?”

Talking to the new client en route to the Alfred’s Heart Failure clinic, ‘Chris’ went to the same Uni as me. Did the same course! I tell my anecdote of mathematician Tom Peachey, how I’d been restoring an old BSA and was tardy in attendance at lectures by this angry little man. “You’ll fail and make nothing of your life, Kirwood“, but I shrugged – I was on my way to 98% … Chris agreed, Tom annoyed him too, “so I slept with his girlfriend“.

Karma. Tom may’ve been ultimately right about me, but Chris sure was heartless!

In the most privileged portion of my career, working at the HyperMed clinic with high level of autonomy in dealing with seriously ill patients, there was a fatality. The deceased, Craig, was stage9 MS, and there is no stage10 *. He’d been rushed to ICU repeatedly, including an airlift from the Latrobe Valley. At the committal for trial pathologist Dr Sarah Parsons claimed cause of death was “Too much oxygen“. The planet certainly would benefit if we evolved to breathe CO2 instead, and I hope her team at Monash are working on this. Sure O2 is a vasoconstrictor, which is why hyperbaric is under pressure of around 30ft underwater – every moist tissue then carries oxygen. And this isn’t quackery – Monash’s physicians at the Alfred hospital also have novel uses for hyperbaric eg adjunct therapy in cancer. Perhaps The Age journo misunderstood Sarah’s evidence (after all, she claimed I had ‘no medical background’ despite the court transcript showing I’ve two decades as a skifield paramedic and a postgrad Dip in Clinical Research)?

Craig also suffered epilepsy. Dr Parson seemingly hasn’t heard that Sudden Unexplained Death in EPilepsy (SUDEP) is actually a thing, despite Prof Chris Semsarian hailing from Sydney and his ‘Post-Mortem Review and Genetic Analysis of SUDEP Cases’ begins: “Sudden unexpected death in epilepsy (SUDEP) is the most frequent epilepsy-related cause of death and is characterized by an absence of any identifiable cause of death…” (Brain Pathology, 2010). And he goes on to point the finger at familial long QT syndrome genes.

QT-interval-long

The QT interval is the time for the heart’s ventricle to get the signal to pump, and then recharge. Long QT can cause otherwise healthy people to suddenly die, and is the #1 monitoring of concern in ‘first-in-humans’ drug trials. The anti-epileptic drug Lyrica/pregabalin is known to lengthen QT in rabbits, but there’s no data in humans. When Pfizer’s Phillip Berry was asked where’s this key safety info, the reply was Dunno. Yet he received Medicine Australia’s Code of Conduct Award in 2013! Pfizer’s chief pharmacist Manal Nessim also couldn’t help.

The US FDA’s approval letter of Lyrica for neuropathic pain section Safety Q19 “Has the applicant submitted adequate information to assess the arythmogenic potential of the product e.g., QT interval studies?” is answered NA. And Q25 “Have narrative summaries been submitted for all deaths and adverse dropouts?” is answered No (will request from sponsor).

Craig was on many drugs, including Lyrica. But the chiropractor killed him, right everyone?

* Stage classification is now obsolete.

Cochrane and Gotzsche

Marcellus: Something is rotten in the state of Denmark (Hamlet 1.4.5)

These words, spoken to Horatio and Hamlet as they look upon wanton and drunken behavior, which has destroyed the nation’s reputation, are apt to the sacking of Danish Prof Gotzsche by the Cochrane Collaboration – the gold standard in medical evidence. Archie Cochrane founded an independent scrutineering of medical trials in 1993, so as to impartially evaluate claims of drug efficacy. Rules and tools for trainsmashing data from systematically gathered results are intended to provide an overview of pros and cons. Peter Gotzsche was an early appointee, directing the Nordic Centre of six neighbouring countries. The last half a dozen years has seen increasingly vocal criticism of commercial influence, and doubters of the Cochrane ideal often focused on mental health solutions. Gotzsche was stubbornly strident in criticism of psychiatry, disregarding my advisory sent 5th Nov ’14 that his condemnation of the profession as being the most lucrative for industry kickbacks was wrong – per his reference it was actually 4th most (in Australia 2009), with rheumatology #1. The download of a chapter ‘Pushing children into suicide with happy pills’ , linked in the flyer for his 2015 Mentalaz tour, concludes thus: Our citizens would be far better off if we removed all the psychotropic drugs from the market, as doctors are unable to handle them.

Followon book to ‘Deadly Medicines and Organised Crime’

Not that the rheumies were off the hook. Peter’s 1989 ‘Methodology and overt and hidden bias in reports of 196 double-blind trials of nonsteroidal anti-inflammatory drugs in rheumatoid arthritis’ warned that “the quality of RCT trials in rheumatology may be so weak that it may be impossible to place any confidence in the … conclusion“. And on pg84 of Deadly Medicines “A rare admission that doctors’ opinions are for sale to the highest bidder was provided by Canadian rheumatologist Peter Tugwell, who wrote a letter to several major companies soliciting funds for CME conferences on behalf of an organisation called OMERACT: We think that support for such a meeting would be very profitable for a company with a worldwide interest in drugs targeted in these field.” Gotzsche aint a team player. Tugwell co-authored with Gotzsche, as well as 19 times with revered Cochrane founder Dave Sackett, whose HARLOTplc article at least gave humour to the reality that their business is for profit.

This month Cochrane’s Governing Board sacked Gotzsche, sparking outcry and protest resignations by 4 other of its 13 members. Six weeks earlier he’d written a critique of a Cochrane review for the HPV vaccine’s efficacy against cervical cancer. Peter’s team had worked on this since Jan 2017, when their analysis protocol was published. Points of disagreement raised were uncontroversial and moot, other than that the outcome of concern only developed after such a long time that surrogate indicators of lesions were instead analysed as being predictive of protection. Rather than dismissal being an exasperated or last straw reaction, the timing was merely coincidental. The Board’s statement informs us that lawyers had been on Gotzsche’s case since March, with a QC conducted independent review underway a month before publishing of the HPV challenge caused contention.

I suggest coincidence, rather than ruse, since the February trigger was possibly a letter attacking a Cochrane chief editor – Andrea Cipriani of the Common Mental Disorders group, over their recent review of 21 anti-depressants as being flawed and untrustworthy. However that team declare no conflicted-interest, and perusal reveals no alarming endorsements. Yet there’s no reference to the unwarranted attack or its target in the Board’s attempt at damage control – is this to protect the privacy of an innocent party, from their shaming by a woefully ill-informed press? Another, diplomatically worded re-analysis of Cipriani’s earlier 2009 anti-depressant report did highlight shortcomings of trial quality assessments, cautioning against the endorsement given for Pfizer’s Zoloft.

The muddy waters turn darkly Stygian.  Cipriani is Prof of Psychiatry at Oxford, which also homes Cochrane’s Pain & Palliative group under Prof Robert Andrew Moore (aka RAM, aka Andrew Moore), whose authoring name varies with context – independent and impartial, or sponsored spokesperson. There’s much overlap between pharmacotherapies with these groups, notably duloxetine/Cymbalta. Cochrane Editor-in-Chief David Tovey would be aware of the industry influence, since he acknowledged an email in March 2015 titled: ‘A 2nd Cochrane group is recruited’ – complaining about the rheumatology group and also including this: [Dr Nnoaham’s] 2008 Cochrane review on TENS for chronic pain and fibromyalgia was censored by your organisation’s Pain, Palliative and Supportive care (PaPaS) editors. Who are excellent examples of transparency, by not hiding their allegiances. Phil Wiffen and Andrew Moore et al chose to include a Pfizer employee in 2010 when conducting their own review into anti-convulsants for pain – surprisingly finding that “For gabapentin and pregabalin only we found reasonably good second tier evidence for efficacy..” (quoting the 2013 update). They reckon duloxetine’s pretty good too – http://www.bmj.com/content/348/bmj.g139/rapid-responses (well you would if you were paid as a consultant by Eli-Lilly, wouldn’t you?)

Grounds for disallowing Nnoaham’s complementary therapy review were that it shall be split into two reviews of TENS – one for fibromyalgia, and one for neuropathy. Except that Wiffen and Moore’s 2013 ‘Lamotrigine (an antiepileptic drug) for chronic neuropathic pain or fibromyalgia’ is an allowable combo! PaPaS also censored an unfavourable review of Pfizer’s gabapentin & pregabalin for pain relief in fibromyalgia on the grounds that lead author Nurcan Üçeyler had been paid speaker’s fees by Pfizer at neurology conferences. However Cochrane’s rule that neither the majority of authors nor the lead can be on the manufacturer’s payroll was also broken by their 2014 review into Neurontin/gabapentin, although Moore then complied in their 2017 update – by re-arranging the order of names to put Phil Wiffen first.

This is a coverup of misconduct. A façade. Gotzsche was certainly going beyond boundaries of expertise, and using his senior position within Cochrane to add weight to his personal opinions, which is contrary to the spokesperson policy allowing only statements on behalf of the collaboration. Years of emotive rants took a toll on his reputation – a tragic folly, when misconduct was there for all to see.

Disclaimer: I consider that the psychiatric profession takes prescribing of psychotropic meds VERY seriously, but worry about GPs playing at amateur shrink on the basis of dubious research evidence. I do not endorse Prof Gotzsche’s attitude, best expressed in his memo to Dr Dawson “Incidentally, I found out that some one has written about you and the way you treated my paper about the 10 myths in psychiatry. See attached [‘Asshole of the day – George Dawson MD’]”. George seems rather professional, actually: http://www.youtube.com/watch?v=ZyINjdCXkAQ